PMID:10418146
| Citation |
Tanabe, K, Kondo, T, Onodera, Y and Furusawa, M (1999) A conspicuous adaptability to antibiotics in the Escherichia coli mutator strain, dnaQ49. FEMS Microbiol. Lett. 176:191-6 |
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| Abstract |
By repeating the cycle of mutagenesis and selection, the Escherichia coli dnaQ49 mutator acquired high level resistance to ampicillin (30,000 micrograms ml-1), streptomycin (26,000 micrograms ml-1) and ofloxacin (3000 micrograms ml-1). Under the strong pressure of ofloxacin, dnaQ49 also followed the history of mutations in the gyrase and topoisomerase i.v. genes previously observed in clinical isolates of quinolone-resistant E. coli. The results of these in vitro experiments suggest that naturally existing mutators may participate in the rapid acquisition of resistance to various antibiotics in patients. A possible mechanism for the occurrence of this adaptability is discussed with special reference to the property of mutagenesis accompanying DNA replication. |
| Links | |
| Keywords |
Amino Acid Sequence; Ampicillin Resistance/physiology; DNA Gyrase; DNA Topoisomerase IV; DNA Topoisomerases, Type II/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Molecular Sequence Data; Mutation; Ofloxacin/pharmacology; Quinolones/pharmacology; Streptomycin/pharmacology |
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