PMID:10393268
| Citation |
Ikehata, M, Koana, T, Suzuki, Y, Shimizu, H and Nakagawa, M (1999) Mutagenicity and co-mutagenicity of static magnetic fields detected by bacterial mutation assay. Mutat. Res. 427:147-56 |
|---|---|
| Abstract |
Possible mutagenic and co-mutagenic effects of strong static magnetic fields were estimated using bacterial mutagenicity test. Mutagenic potential of static magnetic fields up to 5T (T:1T=10,000 G) was not detected by the bacterial mutagenicity test using four strains of Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and Escherichia coli WP2 uvrA either in the pre-incubation method or in the plate incorporation method. In the co-mutagenicity test, E. coli WP2 uvrA cells were treated with various chemical mutagens and were simultaneously exposed to a 2T or a 5T static magnetic field. Mutation rate in the exposed group was significantly higher than that in the non-exposed group when cells were treated with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), ethylmethanesulfonate (EMS), 4-nitroquinoline-N-oxide (4-NQO), 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) or 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2). The mutagenicity of 2-aminoanthracene (2-AA), 9-aminoacridine (9-AA), N4-aminocytidine and 2-acetoamidofluorene (2-AAF) was not affected by the magnetic field exposure. Possible mechanisms of the co-mutagenicity of magnetic fields are discussed. |
| Links | |
| Keywords |
Animals; Bacteria/genetics; Cell Division; Escherichia coli/genetics; Liver/metabolism; Magnetics/adverse effects; Methylnitronitrosoguanidine/analogs & derivatives; Methylnitronitrosoguanidine/pharmacology; Mutagenicity Tests; Mutagens/pharmacology; Mutation; Rats; Salmonella typhimurium/genetics |
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