PMID:10383473
| Citation |
Elofsson, A and Sonnhammer, EL (1999) A comparison of sequence and structure protein domain families as a basis for structural genomics. Bioinformatics 15:480-500 |
|---|---|
| Abstract |
Protein families can be defined based on structure or sequence similarity. We wanted to compare two protein family databases, one based on structural and one on sequence similarity, to investigate to what extent they overlap, the similarity in definition of corresponding families, and to create a list of large protein families with unknown structure as a resource for structural genomics. We also wanted to increase the sensitivity of fold assignment by exploiting protein family HMMs. |
| Links | |
| Keywords |
Computational Biology; Databases, Factual; Genome; Protein Folding; Proteins/chemistry; Proteins/classification; Proteins/genetics; Sequence Alignment; Sequence Homology, Amino Acid |
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