PMID:10350060
| Citation |
Itoh, T, Okayama, T, Hashimoto, H, Takeda, J, Davis, RW, Mori, H and Gojobori, T (1999) A low rate of nucleotide changes in Escherichia coli K-12 estimated from a comparison of the genome sequences between two different substrains. FEBS Lett. 450:72-6 |
|---|---|
| Abstract |
Two genome sequences of Escherichia coli K-12 substrains, one partial W3110 and one complete MG1655, have been determined by Japanese and American genome projects, respectively. In order to estimate the rate of nucleotide changes, we directly compared 2 Mb of the nucleotide sequences from these closely-related E. coli substrains. Given that the two substrains separated about 40 years ago, the rate of nucleotide changes was estimated to be less than 10(-7) per site per year. This rate was supported by a further comparison between partial genome sequences of E. coli and Shigella flexneri. |
| Links | |
| Keywords |
Escherichia coli/genetics; Evolution, Molecular; Genome, Bacterial; Japan; Molecular Sequence Data; Mutation; Nucleotides/genetics; Sequence Alignment; Serology; Shigella flexneri/genetics; Time Factors; United States |
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