PMID:10220403
| Citation |
Raskin, DM and de Boer, PA (1999) Rapid pole-to-pole oscillation of a protein required for directing division to the middle of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 96:4971-6 |
|---|---|
| Abstract |
Accurate placement of the division septum at the midpoint of Escherichia coli cells requires the combined action of a general division inhibitor (MinC), a site-specific suppressor of division inhibition (MinE), and an ATPase (MinD) that is required for proper functioning of both MinC and MinE. We previously showed that a functional MinE-Gfp fusion accumulates in a ring structure at/near the middle of cells. Here we show that functional Gfp-MinD accumulates alternately in either one of the cell halves in what appears to be a rapidly oscillating membrane association-dissociation cycle imposed by MinE. The results indicate that MinD represents a novel type of dynamic cellular element in bacteria, with multiple roles in directing the division apparatus to the middle of the cell. |
| Links | |
| Keywords |
Adenosine Triphosphatases/physiology; Bacterial Proteins/physiology; Cell Division/physiology; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins; Membrane Proteins/physiology |
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