PMID:10217796
| Citation |
Chalut, C, Remy, MH and Masson, JM (1999) Disulfide bridges are not involved in penicillin-binding protein 1b dimerization in Escherichia coli. J. Bacteriol. 181:2970-2 |
|---|---|
| Abstract |
PBP1b can be found as a dimer in Escherichia coli. Previous results suggested that dimerization involved the cysteine(s) in an intermolecular disulfide bond. We show that either deletion mutants or a mutant without cysteines is fully active and still binds penicillin and that the latter can also form dimers. |
| Links | |
| Keywords |
Bacterial Proteins; Carrier Proteins; Cysteine/genetics; Dimerization; Disulfides; Escherichia coli; Escherichia coli Proteins; Hexosyltransferases/chemistry; Hexosyltransferases/genetics; Hexosyltransferases/metabolism; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism; Multienzyme Complexes/chemistry; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Muramoylpentapeptide Carboxypeptidase; Mutation; Penicillin-Binding Proteins; Peptidoglycan; Peptidoglycan Glycosyltransferase; Peptidyl Transferases/chemistry; Peptidyl Transferases/genetics; Peptidyl Transferases/metabolism; Protein Denaturation; Serine-Type D-Ala-D-Ala Carboxypeptidase |
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