PMID:10198039
| Citation |
Nedea, EC, Markov, D, Naryshkina, T and Severinov, K (1999) Localization of Escherichia coli rpoC mutations that affect RNA polymerase assembly and activity at high temperature. J. Bacteriol. 181:2663-5 |
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| Abstract |
We localized five rpoC (beta') mutations affecting Escherichia coli RNA polymerase assembly. The Ts4, XH56, and R120 mutations changed beta' residues conserved throughout eubacteria; the JE10092 mutation occurred in the hypervariable region; rpoC1 (TsX) changed a universally conserved residue and corresponds to yeast rpb1-1. Thus, distinct, predominantly conserved beta' residues participate in interactions holding RNA polymerase together. |
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| Keywords |
Amino Acid Sequence; Conserved Sequence; DNA-Directed RNA Polymerases/biosynthesis; DNA-Directed RNA Polymerases/genetics; DNA-Directed RNA Polymerases/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Molecular Sequence Data; Point Mutation; Protein Binding; Sequence Homology, Amino Acid |
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