PMID:10191387

Citation	Saier, MH Jr Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol. Bioeng. 58:170-4
Abstract	Catabolite repression is a universal phenomenon, found in virtually all living organisms. These organisms range from the simplest bacteria to higher fungi, plants, and animals. A mechanism involving cyclic AMP and its receptor protein (CRP) in Escherichia coli was established years ago, and this mechanism has been assumed by many to serve as the prototype for catabolite repression in all organisms. However, recent studies have shown that this mechanism is restricted to enteric bacteria and their close relatives. Cyclic AMP-independent mechanisms of catabolite repression occur in other bacteria, yeast, plants, and even E. coli. In fact, single-celled organisms such as E. coli, Bacillus subtilis, and Saccharomyces cerevisiae exhibit multiple mechanisms of catabolite repression, and most of these are cyclic AMP-independent. The mechanistic features of the best of such characterized processes are briefly reviewed, and references are provided that will allow the reader to delve more deeply into these subjects.
Links	PubMed
Keywords	Bacillus subtilis/metabolism; Bacteria/metabolism; Carbon/metabolism; Escherichia coli/metabolism; Models, Biological; Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism
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