PMID:10189717
| Citation |
Blackstock, WP and Weir, MP (1999) Proteomics: quantitative and physical mapping of cellular proteins. Trends Biotechnol. 17:121-7 |
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| Abstract |
Genome sequencing provides a wealth of information on predicted gene products (mostly proteins), but the majority of these have no known function. Two-dimensional gel electrophoresis and mass spectrometry have, coupled with searches in protein and EST databases, transformed the protein-identification process. The proteome is the expressed protein complement of a genome and proteomics is functional genomics at the protein level. Proteomics can be divided into expression proteomics, the study of global changes in protein expression, and cell-map proteomics, the systematic study of protein-protein interactions through the isolation of protein complexes. |
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| Keywords |
Biotechnology/trends; Genome; Mass Spectrometry/trends; Peptide Mapping/trends; Proteins/analysis; Proteins/genetics; Proteins/isolation & purification |
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