PMID:10099128
| Citation |
O'Brien, PJ and Herschlag, D (1999) Catalytic promiscuity and the evolution of new enzymatic activities. Chem. Biol. 6:R91-R105 |
|---|---|
| Abstract |
Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution. |
| Links |
PubMed Online version:10.1016/S1074-5521(99)80033-7 |
| Keywords |
Bacteria/enzymology; Catalysis; Enzymes/chemistry; Enzymes/genetics; Enzymes/metabolism; Evolution, Molecular; Humans; Models, Molecular; Protein Engineering |
| edit table |
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