PMID:10097071
| Citation |
Liochev, SI, Hausladen, A and Fridovich, I (1999) Nitroreductase A is regulated as a member of the soxRS regulon of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 96:3537-9 |
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| Abstract |
Nitroreductase A catalyzes the divalent reduction of nitro compounds, quinones, and dyes by NADPH. In this paper, nitroreductase A is induced in Escherichia coli by exposure to paraquat in a manner that depends on the expression of soxR. Nitroreductase activity was only slightly induced by paraquat in a strain bearing a mutational defect in the gene encoding nitroreductase A, but it was approximately 3-fold induced in the parental strain. Nitroreductase A thus appears to be a member of the soxRS regulon and probably contributes to the defenses against oxidative stress by minimizing the redox cycling attendant upon the univalent reduction of nitro compounds, quinones, and dyes. |
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| Keywords |
Drug Resistance, Neoplasm; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial/drug effects; Gene Expression Regulation, Enzymologic/drug effects; Mutagenesis; NAD/metabolism; Nitroreductases/biosynthesis; Nitroreductases/genetics; Paraquat/pharmacology; Regulon |
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