PMID:10095139
| Citation |
Foster, PL (1999) Are adaptive mutations due to a decline in mismatch repair? The evidence is lacking. Mutat. Res. 436:179-84 |
|---|---|
| Abstract |
The levels of proteins required for methyl-directed mismatch repair appear to decline in stationary-phase and nutritionally-deprived cells of Escherichia coli. It has been hypothesized that error-correction by the system also declines, and this decline is responsible for adaptive or stationary-phase mutations. However, evidence in support of this hypothesis is lacking. The mismatch repair system is no less effective in correcting errors during prolonged selection than it is during growth. Furthermore, mismatch repair proteins supplied in excess reduce both growth-dependent and adaptive mutation. |
| Links | |
| Keywords |
Adaptation, Physiological; Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Base Pair Mismatch; DNA Repair/genetics; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Lac Operon; Models, Genetic; Mutation; Selection, Genetic; Tetracycline Resistance/genetics |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.