PMID:10092630
| Citation |
Liochev, SI, Benov, L, Touati, D and Fridovich, I (1999) Induction of the soxRS regulon of Escherichia coli by superoxide. J. Biol. Chem. 274:9479-81 |
|---|---|
| Abstract |
The soxRS regulon orchestrates a multifaceted defense against oxidative stress, by inducing the transcription of approximately 15 genes. The induction of this regulon by redox agents, known to mediate O-2 production, led to the view that O-2 is one signal to which it responds. However, redox cycling agents deplete cellular reductants while producing O-2, and one may question whether the regulon responds to the depletion of some cytoplasmic reductant or to O-2, or both. We demonstrate that raising [O-2] by mutational deletion of superoxide dismutases and/or by addition of paraquat, both under aerobic conditions, causes induction of a member of the soxRS regulon and that a mutational defect in soxRS eliminates that induction. This establishes that O-2, directly or indirectly, can cause induction of this defensive regulon. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli Proteins; Fumarate Hydratase/biosynthesis; Fumarate Hydratase/genetics; Gene Expression Regulation, Bacterial/drug effects; Gene Expression Regulation, Enzymologic/drug effects; Models, Chemical; Regulon/drug effects; Sequence Deletion; Superoxides/pharmacology; Trans-Activators; Transcription Factors/genetics |
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