PMID:10068993

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Citation

Silversmith, RE and Bourret, RB (1999) Throwing the switch in bacterial chemotaxis. Trends Microbiol. 7:16-22

Abstract

In Escherichia coli chemotaxis, the switch from counterclockwise to clockwise rotation of the flagella occurs as a result of binding of the phosphorylated CheY protein to the base of the flagellum. Analysis of CheY variants has provided a picture of the surface of CheY that undergoes conformational shifts, as a result of phosphorylation, to interact directly with the flagellum. Whether phospho-CheY binding and flagellar switching are sequential steps or can occur in a concerted fashion has yet to be determined.

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PubMed

Keywords

Bacterial Proteins/metabolism; Chemotaxis; Escherichia coli/genetics; Escherichia coli/physiology; Flagella/metabolism; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism; Models, Biological; Signal Transduction

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