GGDEF

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GGDEF proteins catalyze the formation of the second messenger cyclic di-GMP through the cyclization of two GTP molecules. Overexpression of cyclic di-GMP has been shown to be toxic in E. coli BL21 strains but not in DH5α [1].

References

  1. ↑ Ryjenkov, DA et al. (2005) Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain. J. Bacteriol. 187 1792-8 PubMed
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