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Description (originally from EcoCyc[1][2]) recBCD

Comments (originally from EcoCyc[1][2]) RecB, RecC, and RecD make up a helicase/nuclease complex that is essential for both homologous recombination during the course of transduction and conjugation as well as in repair of double-strand breaks in Escherichia coli [3][4][5][6][7][7][8][9][10].


  1. 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. Courcelle, J & Hanawalt, PC (2003) RecA-dependent recovery of arrested DNA replication forks. Annu. Rev. Genet. 37 611-46 PubMed
  4. Meddows, TR et al. (2004) RecG helicase promotes DNA double-strand break repair. Mol. Microbiol. 52 119-32 PubMed
  5. Kuzminov, A (1999) Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda. Microbiol. Mol. Biol. Rev. 63 751-813, table of contents PubMed
  6. Muskavitch, KM & Linn, S (1982) A unified mechanism for the nuclease and unwinding activities of the recBC enzyme of Escherichia coli. J. Biol. Chem. 257 2641-8 PubMed
  7. 7.0 7.1 Dillingham, MS et al. (2003) RecBCD enzyme is a bipolar DNA helicase. Nature 423 893-7 PubMed
  8. Stahl, FW (1979) Special sites in generalized recombination. Annu. Rev. Genet. 13 7-24 PubMed
  9. Kulkarni, A & Julin, DA (2004) Specific inhibition of the E.coli RecBCD enzyme by Chi sequences in single-stranded oligodeoxyribonucleotides. Nucleic Acids Res. 32 3672-82 PubMed
  10. Singleton, MR et al. (2004) Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. Nature 432 187-93 PubMed

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