Category:Complex:pyruvate dehydrogenase multienzyme complex
About
Description (originally from EcoCyc[1][2]) pyruvate dehydrogenase multienzyme complex
Comments (originally from EcoCyc[1][2]) The reaction is the gateway to the TCA cycle, producing acetylCoA for the first reaction. It is similar in composition and action to the 2-oxoglutarate dehydrogenase multi-enzyme complex. In animals, the reaction is regulated by phosphorylation of the E1 component, but not in E. coli. It is a multi-enzyme complex composed of three separate enzyme complexes and carries out the following series of reactions where E1, 2 and 3 are the three enzyme complexes making up the multi-enzyme complex. The complex is referred to as the pyruvate dehydrogenase multi-enzyme complex. [3]
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Patel, MS & Roche, TE (1990) Molecular biology and biochemistry of pyruvate dehydrogenase complexes. FASEB J. 4 3224-33 PubMed
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