Category:Complex:primosome
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Description (originally from EcoCyc[1]) primosome
Comments (originally from EcoCyc[1]) The primosome is a six-protein complex that appears to be involved in restart of stalled replication forks, as well as in replication initiation in certain phages and plasmids. See the individual subunit entries for additional information on the function of the primosome.
The primosome undergoes ordered assembly beginning with PriA binding to DNA. Following this, PriB binds to PriA, then DnaT binds. After this, DnaC loads DnaB in an ATP-dependent manner. DnaG associates with the complex and synthesizes an RNA primer [2][3]. Note that the primosome components have many functions in the cell that do not require the full primosome.
References
- ↑ 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Ng, JY & Marians, KJ (1996) The ordered assembly of the phiX174-type primosome. I. Isolation and identification of intermediate protein-DNA complexes. J. Biol. Chem. 271 15642-8 PubMed
- ↑ Ng, JY & Marians, KJ (1996) The ordered assembly of the phiX174-type primosome. II. Preservation of primosome composition from assembly through replication. J. Biol. Chem. 271 15649-55 PubMed
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