Category:Complex:holo-(acyl-carrier-protein) synthase
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Description (originally from EcoCyc[1][2]) holo-[acyl-carrier-protein] synthase
Comments (originally from EcoCyc[1][2]) The holo-ACP synthase enzyme transfers the 4-phosphopantetheine moeity of CoA to the apo-ACP to form holo-ACP, which is the active form of the carrier in lipid synthesis [3][4][5][5][6][7][8][9][10][11][6][6][6][12][6][12][13][13][12][13][12][5].
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Elovson, J & Vagelos, PR (1968) Acyl carrier protein. X. Acyl carrier protein synthetase. J. Biol. Chem. 243 3603-11 PubMed
- ↑ Polacco, ML & Cronan, JE Jr (1981) A mutant of Escherichia coli conditionally defective in the synthesis of holo-[acyl carrier protein]. J. Biol. Chem. 256 5750-4 PubMed
- ↑ 5.0 5.1 5.2 Lambalot, RH & Walsh, CT (1995) Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270 24658-61 PubMed
- ↑ 6.0 6.1 6.2 6.3 6.4 Gehring, AM et al. (1997) Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. Chem. Biol. 4 17-24 PubMed
- ↑ Jaworski, JG et al. (1989) Site-directed mutagenesis of the spinach acyl carrier protein-I prosthetic group attachment site. Eur. J. Biochem. 184 603-9 PubMed
- ↑ Broadwater, JA & Fox, BG (1999) Spinach holo-acyl carrier protein: overproduction and phosphopantetheinylation in Escherichia coli BL21(DE3), in vitro acylation, and enzymatic desaturation of histidine-tagged isoform I. Protein Expr. Purif. 15 314-26 PubMed
- ↑ Tropf, S et al. (1998) Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems. Chem. Biol. 5 135-46 PubMed
- ↑ Debabov, DV et al. (1996) The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC. J. Bacteriol. 178 3869-76 PubMed
- ↑ Ritsema, T et al. (1998) Functional analysis of an interspecies chimera of acyl carrier proteins indicates a specialized domain for protein recognition. Mol. Gen. Genet. 257 641-8 PubMed
- ↑ 12.0 12.1 12.2 12.3 Carreras, CW et al. (1997) Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry 36 11757-61 PubMed
- ↑ 13.0 13.1 13.2 Cox, RJ et al. (1997) Post-translational modification of heterologously expressed Streptomyces type II polyketide synthase acyl carrier proteins. FEBS Lett. 405 267-72 PubMed
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