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Description (originally from EcoCyc[1][2]) MCP-III

Comments (originally from EcoCyc[1][2]) The trg gene product is one of four methyl-accepting chemotaxis proteins (MCPs) in E. coli. MCP-III is the receptor for the attractants ribose and galactose. MCP-III interacts with the periplasmic ribose- or galactose-binding proteins to mediate taxis to these attractants. It is also thermosensitive. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][14][22][23][15][24][25][26].


  1. 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. Baumgartner, JW & Hazelbauer, GL (1996) Mutational analysis of a transmembrane segment in a bacterial chemoreceptor. J. Bacteriol. 178 4651-60 PubMed
  4. Nowlin, DM et al. (1987) Sites of covalent modification in Trg, a sensory transducer of Escherichia coli. J. Biol. Chem. 262 6039-45 PubMed
  5. Lee, GF et al. (1994) Deducing the organization of a transmembrane domain by disulfide cross-linking. The bacterial chemoreceptor Trg. J. Biol. Chem. 269 29920-7 PubMed
  6. Yamamoto, K et al. (1990) Repellent response functions of the Trg and Tap chemoreceptors of Escherichia coli. J. Bacteriol. 172 383-8 PubMed
  7. Yaghmai, R & Hazelbauer, GL (1993) Strategies for differential sensory responses mediated through the same transmembrane receptor. EMBO J. 12 1897-905 PubMed
  8. Nara, T et al. (1991) Thermosensing ability of Trg and Tap chemoreceptors in Escherichia coli. J. Bacteriol. 173 1120-4 PubMed
  9. Park, C et al. (1990) Effects of glutamines and glutamates at sites of covalent modification of a methyl-accepting transducer. J. Bacteriol. 172 7179-87 PubMed
  10. Lee, GF et al. (1995) Transmembrane signaling characterized in bacterial chemoreceptors by using sulfhydryl cross-linking in vivo. Proc. Natl. Acad. Sci. U.S.A. 92 3391-5 PubMed
  11. Hazelbauer, GL et al. (1989) Adaptational "crosstalk" and the crucial role of methylation in chemotactic migration by Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 86 1448-52 PubMed
  12. Bollinger, J et al. (1984) Structure of the Trg protein: Homologies with and differences from other sensory transducers of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 81 3287-91 PubMed
  13. Kondoh, H et al. (1979) Identification of a methyl-accepting chemotaxis protein for the ribose and galactose chemoreceptors of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 76 260-4 PubMed
  14. 14.0 14.1 Manson, MD et al. (1998) Bacterial locomotion and signal transduction. J. Bacteriol. 180 1009-22 PubMed
  15. 15.0 15.1 Falke, JJ et al. (1997) The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu. Rev. Cell Dev. Biol. 13 457-512 PubMed
  16. Gegner, JA et al. (1992) Assembly of an MCP receptor, CheW, and kinase CheA complex in the bacterial chemotaxis signal transduction pathway. Cell 70 975-82 PubMed
  17. Shimizu, TS et al. (2000) Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nat. Cell Biol. 2 792-6 PubMed
  18. Bren, A & Eisenbach, M (2000) How signals are heard during bacterial chemotaxis: protein-protein interactions in sensory signal propagation. J. Bacteriol. 182 6865-73 PubMed
  19. Welch, M et al. (1993) Phosphorylation-dependent binding of a signal molecule to the flagellar switch of bacteria. Proc. Natl. Acad. Sci. U.S.A. 90 8787-91 PubMed
  20. Barak, R & Eisenbach, M (1992) Correlation between phosphorylation of the chemotaxis protein CheY and its activity at the flagellar motor. Biochemistry 31 1821-6 PubMed
  21. Hess, JF et al. (1987) Protein phosphorylation is involved in bacterial chemotaxis. Proc. Natl. Acad. Sci. U.S.A. 84 7609-13 PubMed
  22. Yeh, JI et al. (1993) The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. J. Biol. Chem. 268 9787-92 PubMed
  23. Toews, ML et al. (1979) Attractants and repellents control demethylation of methylated chemotaxis proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 76 5544-8 PubMed
  24. Sourjik, V & Berg, HC (2000) Localization of components of the chemotaxis machinery of Escherichia coli using fluorescent protein fusions. Mol. Microbiol. 37 740-51 PubMed
  25. Borkovich, KA et al. (1992) Attenuation of sensory receptor signaling by covalent modification. Proc. Natl. Acad. Sci. U.S.A. 89 6756-60 PubMed
  26. Li, G & Weis, RM (2000) Covalent modification regulates ligand binding to receptor complexes in the chemosensory system of Escherichia coli. Cell 100 357-65 PubMed

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