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Description (originally from EcoCyc[1][2]) MCP-I

Comments (originally from EcoCyc[1][2]) The tsr gene product is one of four methyl-accepting chemotaxis proteins (MCPs) in E. coli. MCP-I is the receptor for the attractant L-serine and related amino acids. It also responds to a variety of repellents and is thermosensitive. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][9][17][18][10][19][20][21].


  1. 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. Ames, P et al. (1996) Methylation segments are not required for chemotactic signalling by cytoplasmic fragments of Tsr, the methyl-accepting serine chemoreceptor of Escherichia coli. Mol. Microbiol. 19 737-46 PubMed
  4. Rice, MS & Dahlquist, FW (1991) Sites of deamidation and methylation in Tsr, a bacterial chemotaxis sensory transducer. J. Biol. Chem. 266 9746-53 PubMed
  5. Kehry, MR & Dahlquist, FW (1982) The methyl-accepting chemotaxis proteins of Escherichia coli. Identification of the multiple methylation sites on methyl-accepting chemotaxis protein I. J. Biol. Chem. 257 10378-86 PubMed
  6. Li, J et al. (1997) The serine chemoreceptor from Escherichia coli is methylated through an inter-dimer process. Biochemistry 36 11851-7 PubMed
  7. Iwama, T et al. (1997) Uncoupling of ligand-binding affinity of the bacterial serine chemoreceptor from methylation- and temperature-modulated signaling states. J. Biol. Chem. 272 13810-5 PubMed
  8. Ames, P & Parkinson, JS (1994) Constitutively signaling fragments of Tsr, the Escherichia coli serine chemoreceptor. J. Bacteriol. 176 6340-8 PubMed
  9. 9.0 9.1 Manson, MD et al. (1998) Bacterial locomotion and signal transduction. J. Bacteriol. 180 1009-22 PubMed
  10. 10.0 10.1 Falke, JJ et al. (1997) The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes. Annu. Rev. Cell Dev. Biol. 13 457-512 PubMed
  11. Gegner, JA et al. (1992) Assembly of an MCP receptor, CheW, and kinase CheA complex in the bacterial chemotaxis signal transduction pathway. Cell 70 975-82 PubMed
  12. Shimizu, TS et al. (2000) Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nat. Cell Biol. 2 792-6 PubMed
  13. Bren, A & Eisenbach, M (2000) How signals are heard during bacterial chemotaxis: protein-protein interactions in sensory signal propagation. J. Bacteriol. 182 6865-73 PubMed
  14. Welch, M et al. (1993) Phosphorylation-dependent binding of a signal molecule to the flagellar switch of bacteria. Proc. Natl. Acad. Sci. U.S.A. 90 8787-91 PubMed
  15. Barak, R & Eisenbach, M (1992) Correlation between phosphorylation of the chemotaxis protein CheY and its activity at the flagellar motor. Biochemistry 31 1821-6 PubMed
  16. Hess, JF et al. (1987) Protein phosphorylation is involved in bacterial chemotaxis. Proc. Natl. Acad. Sci. U.S.A. 84 7609-13 PubMed
  17. Yeh, JI et al. (1993) The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. J. Biol. Chem. 268 9787-92 PubMed
  18. Toews, ML et al. (1979) Attractants and repellents control demethylation of methylated chemotaxis proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 76 5544-8 PubMed
  19. Sourjik, V & Berg, HC (2000) Localization of components of the chemotaxis machinery of Escherichia coli using fluorescent protein fusions. Mol. Microbiol. 37 740-51 PubMed
  20. Borkovich, KA et al. (1992) Attenuation of sensory receptor signaling by covalent modification. Proc. Natl. Acad. Sci. U.S.A. 89 6756-60 PubMed
  21. Li, G & Weis, RM (2000) Covalent modification regulates ligand binding to receptor complexes in the chemosensory system of Escherichia coli. Cell 100 357-65 PubMed

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