Category:Complex:IS2 insertion element repressor InsA

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Description (originally from EcoCyc[1]) IS2 insertion element repressor InsA

Comments (originally from EcoCyc[1]) InsA is a transcriptional repressor for the insertion element IS2.

InsA binds in the left inverted repeat of IS2, upstream from the insA promoter in IS2. InsA represses IS2 gene transcription [2][3][4][5][6][7][8][9][10][11].

This protein object represents the product of multiple, distinct genes that encode proteins of identical amino acid sequence.


  1. 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. Hu, ST et al. (1994) Functional analysis of the 14 kDa protein of insertion sequence 2. J. Mol. Biol. 236 503-13 PubMed
  3. Lei, GS & Hu, ST (1997) Functional domains of the InsA protein of IS2. J. Bacteriol. 179 6238-43 PubMed
  4. Saedler, H & Heiss, B (1973) Multiple copies of the insertion-DNA sequences IS1 and IS2 in the chromosome of E. coli K-12. Mol. Gen. Genet. 122 267-77 PubMed
  5. Hu, M & Deonier, RC (1981) Comparison of IS1, IS2 and IS3 copy number in Escherichia coli strains K-12, B and C. Gene 16 161-70 PubMed
  6. Ronecker, HJ & Rak, B (1987) Genetic organization of insertion element IS2 based on a revised nucleotide sequence. Gene 59 291-6 PubMed
  7. Saedler, H et al. (1974) IS2, a genetic element for turn-off and turn-on of gene activity in E. coli. Mol. Gen. Genet. 132 265-89 PubMed
  8. Besemer, J & Molzberger, C (1977) Transcription of insertion elements IS1 and IS2 in vitro. Mol. Gen. Genet. 153 51-60 PubMed
  9. Hinton, DM & Musso, RE (1982) Transcription initiation sites within an IS2 insertion in a Gal-constitutive mutant of Escherichia coli. Nucleic Acids Res. 10 5015-31 PubMed
  10. Hu, ST et al. (1998) Negative regulation of IS2 transposition by the cyclic AMP (cAMP)-cAMP receptor protein complex. J. Bacteriol. 180 2682-8 PubMed
  11. Umeda, M & Ohtsubo, E (1989) Mapping of insertion elements IS1, IS2 and IS3 on the Escherichia coli K-12 chromosome. Role of the insertion elements in formation of Hfrs and F' factors and in rearrangement of bacterial chromosomes. J. Mol. Biol. 208 601-14 PubMed

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