Category:Complex:EIIHrsA
About
Description (originally from EcoCyc[1]) EIIHrsA
Description (originally from EcoCyc[2]) 2-O-α-mannosyl-D-glycerate transporting phosphotransferase system
Comments (originally from EcoCyc[1]) Frx (HrsA), a putative PTS permease, belongs to the functional superfamily of the phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The PTS transports and simultaneously phosphorylates its sugar substrates in a process called group translocation. Frx presumably takes up an exogenous sugar, releasing the phosphate ester into the cell cytoplasm in preparation for metabolism (1).
Frx is a fructose-like PTS permease with the domain order IIA-IIB-IIC
(2, 3). Nothing is known about its sugar specificity, its function
or regulation of its synthesis. The overall PTS-mediated phosphoryl
transfer reaction, requiring the two general energy coupling proteins
of the PTS, Enzyme I and HPr, as well as the three domains of
the Enzyme II complex is:
--> HPr(his~~P) --> IIA(his~~P) -->
IIB(cys~~P) -(IIC)-> β-glucoside-6-P.Comments (originally from EcoCyc[2]) MngA, a PTS permease, belongs to the functional superfamily of the phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The PTS transports and simultaneously phosphorylates its sugar substrates in a process called group translocation. MngA takes up exogenous 2-O-α-mannosyl-D-glycerate, releasing the phosphate ester into the cell cytoplasm in preparation for metabolism [3].
MngA is a fructose-like PTS permease with the domain order IIA-IIB-IIC
(2, 3). The overall PTS-mediated phosphoryl
transfer reaction, requiring the two general energy coupling proteins
of the PTS, Enzyme I and HPr, as well as the three domains of
the Enzyme II complex is:
--> HPr(his~~P) --> IIA(his~~P) -->
IIB(cys~~P) -(IIC)-> 2-O-(6-phospho-α-mannosyl)-D-glycerate.
References
- ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Sampaio, MM et al. (2004) Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. J. Biol. Chem. 279 5537-48 PubMed
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