Catabolite Repression

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General Description

Catabolite repression describes the negative regulation of catabolism systems in the presence of higher-energy carbon sources, such as glucose. Catabolite is responsible for diauxie, the sequential, rather than simultaneous, utilization of carbon sources in a mixture.

Components

Function

Regulation

Cell Biology

Experimental Resources

Comparison with other organisms

Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms. Lengeler JW, Jahreis K. Contrib Microbiol. 2009;16:65-87. [1]

Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Görke B, Stülke J. Nat Rev Microbiol. 2008 Aug;6(8):613-24. [2]

The mechanisms of carbon catabolite repression in bacteria. Deutscher J. Curr Opin Microbiol. 2008 Apr;11(2):87-93. [3]

How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. Deutscher J, Francke C, Postma PW. Microbiol Mol Biol Rev. 2006 Dec;70(4):939-1031.[4] (Erratum in: Microbiol Mol Biol Rev. 2008 Sep;72(3):555)

Notes

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References

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  1. Lengeler, JW & Jahreis, K (2009) Bacterial PEP-dependent carbohydrate: phosphotransferase systems couple sensing and global control mechanisms. Contrib Microbiol 16 65-87 PubMed
  2. Görke, B & Stülke, J (2008) Carbon catabolite repression in bacteria: many ways to make the most out of nutrients. Nat. Rev. Microbiol. 6 613-24 PubMed
  3. Deutscher, J (2008) The mechanisms of carbon catabolite repression in bacteria. Curr. Opin. Microbiol. 11 87-93 PubMed
  4. Deutscher, J et al. (2006) How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria. Microbiol. Mol. Biol. Rev. 70 939-1031 PubMed