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Azetidine-2-COOH is a proline analog that is incorporated into proteins in vivo in E. coli[1][2][3]


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  1. Nakatogawa, H & Ito, K (2001) Secretion monitor, SecM, undergoes self-translation arrest in the cytosol. Mol. Cell 7 185-92 PubMed
  2. Quick, M et al. (1996) Ser57 in the Na+/proline permease of Escherichia coli is critical for high-affinity proline uptake. Eur. J. Biochem. 239 732-6 PubMed
  3. Hayes, CS et al. (2002) Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination. J. Biol. Chem. 277 33825-32 PubMed