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  • It was found that in order to be effective in intact cells, albicidin concentration had to be increase 100-fold to completely inhibit DNA replication in permeabilized cells. Albicidin at lower concentrations caused a slower inhibition of DNA replication. See figure 4 for full experimental results and description.[1]

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  1. Birch, RG et al. (1990) Stable albicidin resistance in Escherichia coli involves an altered outer-membrane nucleoside uptake system. J. Gen. Microbiol. 136 51-8 PubMed