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| Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments | |
|---|---|---|---|---|---|---|---|---|
|
public |
yfiO4 |
C-terminal truncation of 57 nucleotides |
C-terminal truncation of 19 amino acids (-MNAQAEKVAKIIAANSSNT), followed by non-native 10 amino acid tail resulting from drug cassette insertion (+ICLLYTSQPV). |
Partial loss-of-function mutation. Results in lower levels of outer membrane beta-barrel proteins and outer membrane sensitivity. |
Protein encoded by yfiO4 destabilizes BamCDE sub-complex [1], and results in unstable protein at 37 degrees during stationary phase [2] | |||
|
public |
yfiO5 |
C-terminal truncation of 54 nucleotides |
C-terminal truncation of 18 amino acids (-NAQAEKVAKIIAANSSNT), followed by non-native 1 amino acid tail resulting from drug cassette insertion (+V) |
Partial loss-of-function mutation. Results in lower levels of outer membrane beta-barrel proteins and outer membrane sensitivity. |
Protein encoded by yfiO5 destabilizes BamCDE sub-complex [1], and results in unstable protein at 37 degrees during stationary phase [2]. yfiO5 outer membrane sensitivity more severe than yfiO4. |
- ↑ 1.0 1.1 1.2 1.3 Malinverni, JC et al. (2006) YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Mol. Microbiol. 61 151-64 PubMed
- ↑ 2.0 2.1 2.2 2.3 Sklar, JG et al. (2007) Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 104 6400-5 PubMed
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