amtB:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
amtB |
|---|---|
| Gene Synonym(s) |
ECK0445, b0451, JW0441, ybaG[1] |
| Product Desc. |
AmtB ammonium Amt transporter[2]; AmtB[3]; Component of ammonium Amt transporter[3] Ammonia gas channel; sequesters GlnK, a negative regulator of AmtB activity, to the inner membrane; bi-directional facilitated diffusion[4] |
| Product Synonyms(s) |
ammonium transporter[1], B0451[2][1], YbaG[2][1], AmtB[2][1], AmtB ammonium Amt transporter[3][1] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
AmtB is a trimeric inner membrane protein. Each subunit has 11 TM helices; a predicted N-terminal 12th TM helix is actually a cleaved signal peptide. Ammonium is proposed to bind to the periplasmic face of AmtB and then to be deprotonated to ammonia for diffusion through the AmtB channel, then reprotonated by water to hydrate the ammonia gas to ammonium ion in the cytoplasm. AmtB enables growth on ammonium as sole nitrogen source at low ammonium ion concentrations (Soupene, 1998). The human Rh proteins are AmtB homologs and have been variously proposed to act as ammonia channels or as carbon dioxide gas channels.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.