plsY:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
plsY |
|---|---|
| Gene Synonym(s) |
ECK3049, b3059, JW3031[1], ygiH product |
| Product Desc. |
conserved inner membrane protein[2][3] Probable acylphosphate:glycerol-3-phosphate acyltransferase[4] |
| Product Synonyms(s) |
conserved inner membrane protein[1], B3059[2][1], YgiH[2][1] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
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Notes
ygiH(plsY) and plsX are synthetic lethals and cannot be simultaneously deleted, implicating ygiH(plsY) involvement in phospholipid biosynthesis (Yoshimura, 2007). Homologous to the PlsY acylphosphate:glycerol-3-phosphate acyltransferase (UniProt: P0A4Q0) of S. pneumoniae, which identifies a function for the UPF0078 family (COG0344). S. pneumoniae PlsX and PlsY work together as a two-step glycerol-3-phosphate acylation, the first step in phosphatidic acid synthesis, an intermediate in phospholipid synthesis (Lu, 2006). PlsXY homologs are present in E. coli, but PlsXY apparently cannot substitute for the single step reaction catalyzed by PlsB, which is essental in E. coli.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.