thiM:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
| Gene Name | |
|---|---|
| Product(s) |
ThiM product[1]: hydoxyethylthiazole kinase product, B2104 product, 4-methyl-5-(β-hydroxyethyl)thiazole kinase product, ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase product, THZ kinase product |
| Description | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
thiMD operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 5' UTR. The thiM riboswitch is the target for the antibiotic pyrithiamine. The PDB links are to the structures of various thiM riboswitch/small molecule complexes: 2GDI, TPP; 2HOJ, TPP/Mn2+; 2HOK, TPP/Ca2+; 2HOL, TPP/Ba2+; 2HOM,TMP; 2HOO, BTP; 2HOP, PT (Serganov, 2006; Edwards, 2006).[4]
References
- ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.