ispH:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

ispH (synonyms: ECK0030, b0029, JW0027, lytB, yaaE)[1]

Product(s)

IspH product[1]: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein product, B0029 product, YaaE product, LytB product

Description

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase[2][3]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): lsp-fkpB-ispH[2], ribF-ileS-lspA-fkpB-ispH[2], ileS-lsp, ileS-lspA-lytB, ribF-ileS-lspA-slpA-lytB

Regulation/Activity


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Notes

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The ispH gene is essential. IspH contains a [4Fe-4S] cluster. IspH affects penicillin tolerance and the stringent response.[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.