alkB:Quickview

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Gene

Gene Product(s)

Gene Name	alkB (synonyms: ECK2204, b2212, JW2200, aidD)^[1]
Product(s)	AlkB product^[1]: oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions product, B2212 product, AidD product
Description	AlkB repair system for alkylated DNA and RNA^[2]^[3]
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ada-alkB^[2], OP00100, alkB^[2]
Regulation/Activity
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Notes

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AlkB mutants are extremely sensitive to MMS. Also repairs alkylated mRNA and tRNA in vivo and in vitro, the first example of direct RNA repair. Repairs epsilonA and epsilonC. Ada regulon.^[4]

References

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↑ ^1.0 ^1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

[LIB:Riley_2006-1] 1.0 ^1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)

[LIB:EcoCyc10.6-2] 2.0 ^2.1 ^2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

[LIB:EcoCyc11.1-3] EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7

[LIB:EcoGene-4] EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

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[2]

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alkB:Quickview

Notes

References

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