Bicyclomycin
Bicyclomycin discovered in 1972, has a unique structure that differentiates it from all other antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. [1]
to add a reference: Genes in E. coli that affect sensitivity to bicyclomycin.[2]
Mode of Action
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.
Structure
Targets
Bicyclomycin targets the transcription termination factor Rho [3]
Mechanisms of Resistance
Mutations that affect sensitivity
| Gene | Allele | Sensitivity to BCM | Reference |
|---|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
- ↑ Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed
- ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed