mfd:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
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| Standard Name |
mfd |
|---|---|
| Gene Synonym(s) |
ECK1100, b1114, JW1100[1] |
| Product Desc. |
transcription-repair coupling factor[2][3] Transcription repair coupling factor[4] |
| Product Synonyms(s) |
transcription-repair coupling factor[1], B1114[2][1], Mfd[2][1], TRCF[3][1] |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
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Notes
Mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. Arrested (backtracked) RNAP complexes are are also rescued by Mfd promoting forward translocation. Mfd structure resembles UvrB, including UvrA binding site, but no ATP-binding site.[4]
References
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- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.