Quinolones

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About

Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA.

Targets

Type II Topoisomerases

  • DNA Gyrase
  • Topoisomerase IV[1]

Resistant Alleles

  • ParC

Usage Examples and Notes

References

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  1. ↑ Khodursky, AB et al. (1995) Topoisomerase IV is a target of quinolones in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92 11801-5 PubMed
  2. ↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed
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