Quinolones

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About

Binds to Topoisomerase IV and DNA Gyrase to form poisonous adducts on the DNA.

Resistant Alleles

  • ParC
    • wtTopo IV inhibition by norfloxacin reduces its activity to a rate of 1/100 the normal level[1].

Usage Examples and Notes

References

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  1. ↑ Zechiedrich, EL & Cozzarelli, NR (1995) Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9 2859-69 PubMed
  2. ↑ Lopez, CR et al. (2005) A role for topoisomerase III in a recombination pathway alternative to RuvABC. Mol. Microbiol. 58 80-101 PubMed
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