Bicyclomycin

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Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium Micrococcus luteus.[1]


Mode of Action

Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP. [1]

Structure

Targets

Bicyclomycin targets the transcription termination factor Rho [2]

Mechanisms of Resistance

Mutations that affect sensitivity

Genes in E. coli that affect sensitivity to bicyclomycin. <ref name='PMID:21357484'/

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Gene Allele Sensitivity to BCM Reference
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References

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  1. ↑ 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
  2. ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed
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