hha:Quickview: Difference between revisions
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Modulates hemolysin expression, in complex with H-NS; stimulates transposition events; induced by AI-2 pheromone; promotes conjugation and conjugation-induced biofilms<ref name='LIB:EcoGene'/> | Modulates hemolysin expression, in complex with H-NS; stimulates transposition events; induced by AI-2 pheromone; promotes conjugation and conjugation-induced biofilms<ref name='LIB:EcoGene'/> | ||
Hha is a small transcriptional regulator (8 kDa) that is induced in biofilms<ref name='PMID:14727089'/> and that influences biofilm formation<ref name='PMID:16317765'/>; Hha overexpression reduces biofilm formation by increasing biofilm dispersal<ref name='PMID:18545668'/>. Rather than binding to specific DNA sequences, Hha exhibits non-specific DNA binding. Hha binds in vivo to 15 genes or intergenic regions of CP4-57 and DLP12 including regions close to the prophage attachment (att) sites and that Hha activates the prophage lytic genes ''alpA'', ''rzpD'', ''appY'' and ''yfjZ'', as well as induces plaque formation and decreases cell viability<ref name='PMID:18545668'/>. | |||
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Revision as of 16:29, 5 January 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
hha |
|---|---|
| Gene Synonym(s) |
ECK0454, b0460, JW0449[1] |
| Product Desc. |
haemolysin expression modulating protein[2][3] Modulates hemolysin expression, in complex with H-NS; stimulates transposition events; induced by AI-2 pheromone; promotes conjugation and conjugation-induced biofilms[4] Hha is a small transcriptional regulator (8 kDa) that is induced in biofilms[5] and that influences biofilm formation[6]; Hha overexpression reduces biofilm formation by increasing biofilm dispersal[7]. Rather than binding to specific DNA sequences, Hha exhibits non-specific DNA binding. Hha binds in vivo to 15 genes or intergenic regions of CP4-57 and DLP12 including regions close to the prophage attachment (att) sites and that Hha activates the prophage lytic genes alpA, rzpD, appY and yfjZ, as well as induces plaque formation and decreases cell viability[7]. |
| Product Synonyms(s) |
modulator of gene expression, with H-NS[1], B0460[2][1], Hha[2][1] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
Hha and Cnu are paralogs. The expression of the hly operon of plasmid pHly152 is modulatedby Hha/HN-S. Overexpression of Cnu(YdgT) partially suppresses the hha defect on hylA expression. Hha positively modulates H-NS expression. Induced during biofilm formation.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Ren, D et al. (2004) Gene expression in Escherichia coli biofilms. Appl. Microbiol. Biotechnol. 64 515-24 PubMed
- ↑ Barrios, AF et al. (2006) Hha, YbaJ, and OmpA regulate Escherichia coli K12 biofilm formation and conjugation plasmids abolish motility. Biotechnol. Bioeng. 93 188-200 PubMed
- ↑ 7.0 7.1 García-Contreras, R et al. (2008) Protein translation and cell death: the role of rare tRNAs in biofilm formation and in activating dormant phage killer genes. PLoS ONE 3 e2394 PubMed