Category:Complex:FecAR Signal Transduction System: Difference between revisions

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==About==
'''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>) FecAR Signal Transduction System
 
'''Comments''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/>) FecARI are responsible for ferric citrate dependent induction of the ferric citrate
uptake system. When the inducer, ferric citrate, binds FecA, which is also
responsible for transport of ferric citrate across the outer membrane, a signal is
transmitted across the outer membrane to the cytoplasmic membrane protein FecR.
FecR transmits the signal across the cytoplasmic membrane and activates the
&sigma;<sup>70</sup> family protein FecI in the cytoplasm. FecI directs RNA
polymerase to express <I>fecABCDE</I>, which encodes the ferric citrate outer
membrane receptor and the ferric citrate ABC transporter, as well as <I>fecIR</I>
<ref name='PMID:7729419'/><ref name='PMID:10633096'/><ref name='PMID:16333751'/><ref name='PMID:12354617'/><ref name='PMID:7729419'/><ref name='PMID:10633096'/><ref name='PMID:16333751'/><ref name='PMID:12354617'/><ref name='PMID:12732308'/><ref name='PMID:16333751'/><ref name='PMID:16718597'/>
 
 
 
==References==
<references/>

Revision as of 12:32, 20 July 2007

About

Description (originally from EcoCyc[1][2]) FecAR Signal Transduction System

Comments (originally from EcoCyc[1]) FecARI are responsible for ferric citrate dependent induction of the ferric citrate uptake system. When the inducer, ferric citrate, binds FecA, which is also responsible for transport of ferric citrate across the outer membrane, a signal is transmitted across the outer membrane to the cytoplasmic membrane protein FecR. FecR transmits the signal across the cytoplasmic membrane and activates the σ70 family protein FecI in the cytoplasm. FecI directs RNA polymerase to express fecABCDE, which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter, as well as fecIR [3][4][5][6][3][4][5][6][7][5][8]


References

  1. ↑ 1.0 1.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 Härle, C et al. (1995) Signal transfer through three compartments: transcription initiation of the Escherichia coli ferric citrate transport system from the cell surface. EMBO J. 14 1430-8 PubMed
  4. ↑ 4.0 4.1 Enz, S et al. (2000) Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins. J Bacteriol 182 637-46 PubMed
  5. ↑ 5.0 5.1 5.2 Braun, V et al. (2005) Gene regulation by transmembrane signaling. Biometals 18 507-17 PubMed
  6. ↑ 6.0 6.1 Braun, V & Braun, M (2002) Iron transport and signaling in Escherichia coli. FEBS Lett 529 78-85 PubMed
  7. ↑ Braun, V et al. (2003) Regulation of the FecI-type ECF sigma factor by transmembrane signalling. Curr Opin Microbiol 6 173-80 PubMed
  8. ↑ Braun, V et al. (2006) Gene regulation by transmembrane signaling. Biometals 19 103-13 PubMed

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