leuO:Quickview: Difference between revisions
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!align=left {{table_heading_style}} |Standard Name | !align=left {{table_heading_style}} |Standard Name | ||
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''leuO'' | |||
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!align=left {{table_heading_style}} |Gene Synonym(s) | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
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''ECK0078, b0076, JW0075''<ref name='LIB:Riley_2006'/> | |||
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!align=left {{table_heading_style}} |Product Desc. | !align=left {{table_heading_style}} |Product Desc. | ||
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LeuO transcriptional activator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/> | |||
Pleiotropic transcriptional regulator; regulates dsrA; relieves bgl silencing, multi-copy represses cadC<ref name='LIB:EcoGene'/> | |||
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!align=left {{table_heading_style}} |Product Synonyms(s) | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
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DNA-binding transcriptional activator<ref name='LIB:Riley_2006'/>, B0076<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, LeuO<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, affects expression of small regulatory Dsr-RNA<ref name='PMID:9302018' />, translational regulation of rpoS, relieves bgl silencing<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | |||
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!align=left {{table_heading_style}} |Knock-Out Phenotype | !align=left {{table_heading_style}} |Knock-Out Phenotype | ||
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!align=left {{table_heading_style}} |Regulation/Expression | !align=left {{table_heading_style}} |Regulation/Expression | ||
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transcription unit(s): [[:Category:Txn_unit:leuO|leuO]]<ref name='LIB:EcoCyc10.6'/> | |||
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!align=left {{table_heading_style}} |Regulation/Activity | !align=left {{table_heading_style}} |Regulation/Activity | ||
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Revision as of 20:56, 4 March 2009
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
leuO |
|---|---|
| Gene Synonym(s) |
ECK0078, b0076, JW0075[1] |
| Product Desc. |
LeuO transcriptional activator[2][3] Pleiotropic transcriptional regulator; regulates dsrA; relieves bgl silencing, multi-copy represses cadC[4] |
| Product Synonyms(s) |
DNA-binding transcriptional activator[1], B0076[2][1], LeuO[2][1], affects expression of small regulatory Dsr-RNA[5], translational regulation of rpoS, relieves bgl silencing[2][1] |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity |
|
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
LysR-family. leuO is upstream and divergent of the leuABCD operon. LeuO is required for recovery of a relA1 strain from starvation for brached-chain amino acids. In Salmonella, LeuO relieves leuABCD silencing mediated by an AT-rich silencer sequence between leuO and leuA. In Salmonella, LeuO expression is activated by an ilvHI-leuO-leuA promoter relay mechanism mediated by DNA supercoiling, possibly explaining the ppGpp-dependent increase in E. coli LeuO expression in stationary phase as an indirect effect of ppGpp stimulating the expression of Lrp, an ilvHI activator.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Klauck, E et al. (1997) The LysR-like regulator LeuO in Escherichia coli is involved in the translational regulation of rpoS by affecting the expression of the small regulatory DsrA-RNA. Mol. Microbiol. 25 559-69 PubMed