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===Notes===
===Notes===
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NtrC regulon. The rut operon is required for the utilization of thymidine, uridine and cytidine as nitrogen sources at 37C, but not at room temperature. YjgF, RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved YjgF family (pfam:PF01042) with diverse mutant phenotypes and unknown molecular function; the family members form homotrimers, some binding 2-ketoglutarate or related compounds. The rat homolog PSP (perchloric acid-soluble protein) has been reported to have endoribonuclease activity, Endoribonuclease L, against ss mRNA, inhibiting translation, but this activity has not been demonstrated for other members.<ref name='LIB:EcoGene'/>





Revision as of 03:26, 3 March 2009

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

rutC (synonyms: ycdK, ECK1001, b1010, JW0995)[1][2]

Product(s)

YcdK product[1]: conserved protein product, B1010 product, RutC product

Description

predicted endoribonuclease[2][3]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): rutABCDEFG[2]

Regulation/Activity


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Notes

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NtrC regulon. The rut operon is required for the utilization of thymidine, uridine and cytidine as nitrogen sources at 37C, but not at room temperature. YjgF, RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved YjgF family (pfam:PF01042) with diverse mutant phenotypes and unknown molecular function; the family members form homotrimers, some binding 2-ketoglutarate or related compounds. The rat homolog PSP (perchloric acid-soluble protein) has been reported to have endoribonuclease activity, Endoribonuclease L, against ss mRNA, inhibiting translation, but this activity has not been demonstrated for other members.[4]



References

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  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.