PMID:10692383: Difference between revisions
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Revision as of 12:13, 30 April 2008
Rosenberg, EY, Ma, D and Nikaido, H (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump.J. Bacteriol. 182:1754-6
| Abstract | AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain. |
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