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| ==About==
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| '''Description''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>) tryptophan synthase
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| '''Comments''' (originally from EcoCyc<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>) The overall tryptophan synthase reaction consists of a sequence of two partial reactions.
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| The α subunit of the complex carries out the aldol cleavage of indole-3-glycerol phosphate to indole +
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| glyceraldehyde-3-phosphate.
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| The β subunit is responsible for the synthesis of L-tryptophan from indole + L-serine.
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| The α2-β2 complex, which alone catalyzes the overall reaction, proceeds at two
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| independent α/β sites via catalysis of the α reaction on the α subunit component,
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| channeling the product (indole) to the pyridoxal phosphate site on the β component, where, in the
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| presence of L-serine, it is converted to tryptophan. Indole does not appear in solution and is not a free
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| intermediate. There is apparent subunit communication mediated by transduced conformational changes
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| between the subunits, whereby the rates of the α and β reactions are
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| strongly enhanced by, respectively, the β and α subunits <ref name='PMID:2001993'/>.
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| ==References==
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| <references/>
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| [[Category:Complexes]]
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| [[Category:E. coli complexes]]
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Revision as of 15:40, 2 August 2007
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