PMID:372184: Difference between revisions

Revision as of 19:26, 1 September 2013

Citation	No author listed (1979) Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase. J. Biol. Chem. 254:2579-81
Abstract	The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem. 246, 5812-5816), which suggested that ppGpp did not bind at the GTP site. Possible reasons for the discrepancy are discussed. The potency of the ppGpp inhibition is confirmed.
Links	PubMed
Keywords	Adenylosuccinate Synthase/antagonists & inhibitors; Escherichia coli/enzymology; Guanine Nucleotides/pharmacology; Guanosine Tetraphosphate/pharmacology; Guanosine Triphosphate/pharmacology; Inosine Monophosphate/pharmacology; Kinetics; Ligases/antagonists & inhibitors
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