PMID:10692383: Difference between revisions

Revision as of 17:51, 1 September 2013

Citation	No author listed (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-6
Abstract	AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain.
Links	PubMed PMC94475
Keywords	Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests
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