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!align=left |Citation | |||
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'''No author listed''' (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. ''J. Bacteriol.'' '''182''':1754-6 | |||
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!align=left |Abstract | |||
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AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain. | |||
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!align=left |Links | |||
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10692383 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC94475 PMC94475] | |||
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| | !align=left |Keywords | ||
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|- | Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests | ||
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==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
{{LitSignificance}} | {{LitSignificance}} | ||
Revision as of 17:51, 1 September 2013
| Citation |
No author listed (2000) AcrD of Escherichia coli is an aminoglycoside efflux pump. J. Bacteriol. 182:1754-6 |
|---|---|
| Abstract |
AcrD, a transporter belonging to the resistance-nodulation-division family, was shown to participate in the efflux of aminoglycosides. Deletion of the acrD gene decreased the MICs of amikacin, gentamicin, neomycin, kanamycin, and tobramycin by a factor of two to eight, and DeltaacrD cells accumulated higher levels of [(3)H]dihydrostreptomycin and [(3)H]gentamicin than did the parent strain. |
| Links | |
| Keywords |
Aminoglycosides; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Microbial Sensitivity Tests |
| edit table |
Significance
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Useful Materials and Methods
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Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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