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| {{See|Help:Processes|physiological processes}}
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| ==General Description= | | ==General Description= |
| <!-- /* Font Definitions */@font-face {font-family:"ＭＳ 明朝"; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:128; mso-generic-font-family:roman; mso-font-format:other; mso-font-pitch:fixed; mso-font-signature:1 134676480 16 0 131072 0;}@font-face {font-family:"ＭＳ 明朝"; panose-1:0 0 0 0 0 0 0 0 0 0; mso-font-charset:128; mso-generic-font-family:roman; mso-font-format:other; mso-font-pitch:fixed; mso-font-signature:1 134676480 16 0 131072 0;}@font-face {font-family:Cambria; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:3 0 0 0 1 0;} /* Style Definitions */p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"ＭＳ 明朝"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-family:Cambria; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"ＭＳ 明朝"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}@page WordSection1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;}div.WordSection1 {page:WordSecUvrA and UvrB are the first of four known enzymes that assist in excision repair, and are both responsible for scanning the DNA for distortions. Once a genome distortion, such as those caused by a thymine dimer or another chemical adduct on a base, is detected by UvrA, UvrA leaves and UvrB proceeds to melt the DNA, creating a bubble around the lesion. UvrB then recruits UvrC. UvrC cleaves the area of the bubble, including the lesion, creating a short, single-stranded DNA segment that is then removed by DNA helicase, UvrD. The gap that results from the excision is filled by DNA polymerase and DNA ligase using the undamaged strand as a template. Once complete, the original nucleotide sequence is restored.
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| Uvr proteins are necessary to repair damage caused by ultraviolet light in genomes. Mutants of the uvr genes are very sensitive to killing by UV irradiation and are incapable of removing thymine-thymine and thymine-cystine adducts.
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| ==Components== | | ==Components== |
Revision as of 22:56, 24 February 2012
=General Description
Components
Function
Regulation
Cell Biology
Experimental Resources
Comparison with other Organisms
Notes
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Related GO Terms
Help:Gene Ontology
References
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