Bicyclomycin: Difference between revisions
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===Mode of Action=== | ===Mode of Action=== | ||
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP. | Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.<ref name='PMID:16181146'/> | ||
<ref name='PMID:16181146'/> | |||
===Structure=== | ===Structure=== | ||
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===Targets=== | ===Targets=== | ||
Bicyclomycin targets the transcription termination factor Rho | Bicyclomycin targets the transcription termination factor Rho.<ref name='PMID:8466900'/> | ||
<ref name='PMID:8466900'/> | |||
===Mechanisms of Resistance=== | ===Mechanisms of Resistance=== | ||
===Mutations that affect sensitivity=== | ===Mutations that affect sensitivity=== | ||
Genes in ''E. coli'' that affect sensitivity to bicyclomycin. | Genes in ''E. coli'' that affect sensitivity to bicyclomycin.<ref name='PMID:21357484'/> | ||
<ref name='PMID:21357484'/ | |||
<protect><!--box uid=63ce1649aab8b3180235b0af7618f667.180696.R4e84956686066--> | <protect><!--box uid=63ce1649aab8b3180235b0af7618f667.180696.R4e84956686066--> | ||
Revision as of 22:15, 6 October 2011
Bicyclomycin, discovered in 1972, has a structure that is unique among antibiotics. Currently used to treat nonspecific diarrhea, it has a low toxicity, and no cross-resistance with other antibiotics has yet been found. It is effective against many Gram-negative bacteria. Bicyclomycin is also effective against the Gram-positive bacterium Micrococcus luteus.[1]
Mode of Action
Bicyclomycin inhibits Rho by being a reversible, noncompetitive inhibitor of ATP.[1]
Structure
Targets
Bicyclomycin targets the transcription termination factor Rho.[2]
Mechanisms of Resistance
Mutations that affect sensitivity
Genes in E. coli that affect sensitivity to bicyclomycin.[3]
| Gene | Allele | Sensitivity to BCM | Reference |
|---|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
- ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed
- ↑ Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed