Bicyclomycin: Difference between revisions
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===Mode of Action=== | ===Mode of Action=== | ||
<ref name='PMID:16181146'> | <ref name='PMID:16181146'/> | ||
===Structure=== | ===Structure=== | ||
Revision as of 15:04, 6 October 2011
to add a reference: Genes in E. coli that affect sensitivity to bicyclomycin.[1]
Mode of Action
Structure
Targets
Bicyclomycin targets the transcription termination factor Rho [3]
Mechanisms of Resistance
Mutations that affect sensitivity
| Gene | Allele | Sensitivity to BCM | Reference |
|---|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Tran, L et al. (2011) Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J. Bacteriol. 193 2229-35 PubMed
- ↑ Kohn, H & Widger, W (2005) The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord 5 273-95 PubMed
- ↑ Zwiefka, A et al. (1993) Transcription termination factor rho: the site of bicyclomycin inhibition in Escherichia coli. Biochemistry 32 3564-70 PubMed