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<span style = 'font-size: large'> '''Lemke, JJ, Sanchez-Vazquez, P, Burgos, HL, Hedberg, G, Ross, W and Gourse, RL''' (2011) Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA.''Proc. Natl. Acad. Sci. U.S.A.'' '''108''':5712-7</span> | |||
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|{{TableHeadingColor}} |'''Abstract''' || <protect>We show here that the promoters for many of the Escherichia coli ribosomal protein operons are regulated directly by two transcription factors, the small RNA polymerase-binding protein DksA and the nutritional stress-induced nucleotide ppGpp. ppGpp and DksA work together to inhibit transcription initiation from ribosomal protein promoters in vitro and in vivo. The degree of promoter regulation by ppGpp/DksA varies among the r-protein promoters, but some are inhibited almost as much as rRNA promoters. Thus, many r-protein operons are regulated at the level of transcription in addition to their control by the classic translational feedback systems discovered ~30 y ago. We conclude that direct control of r-protein promoters and rRNA promoters by the same signal, ppGpp/DksA, makes a major contribution to the balanced and coordinated synthesis rates of all of the ribosomal components.</protect> | |||
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|{{TableHeadingColor}} nowrap |'''Links''' || | |||
* [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=21402902 PubMed] | |||
Online version:[http://dx.doi.org/10.1073/pnas.1019383108 10.1073/pnas.1019383108] | |||
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Revision as of 23:46, 9 August 2011
Lemke, JJ, Sanchez-Vazquez, P, Burgos, HL, Hedberg, G, Ross, W and Gourse, RL (2011) Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA.Proc. Natl. Acad. Sci. U.S.A. 108:5712-7
| Abstract | <protect>We show here that the promoters for many of the Escherichia coli ribosomal protein operons are regulated directly by two transcription factors, the small RNA polymerase-binding protein DksA and the nutritional stress-induced nucleotide ppGpp. ppGpp and DksA work together to inhibit transcription initiation from ribosomal protein promoters in vitro and in vivo. The degree of promoter regulation by ppGpp/DksA varies among the r-protein promoters, but some are inhibited almost as much as rRNA promoters. Thus, many r-protein operons are regulated at the level of transcription in addition to their control by the classic translational feedback systems discovered ~30 y ago. We conclude that direct control of r-protein promoters and rRNA promoters by the same signal, ppGpp/DksA, makes a major contribution to the balanced and coordinated synthesis rates of all of the ribosomal components. |
|- |bgcolor='#CCCCFF' nowrap |Links ||
Online version:10.1073/pnas.1019383108 |} </protect>
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